Treatment of Zollinger–Ellison Syndrome with Streptozotocin

Abstract

ALTHOUGH streptozotocin has been used successfully in treatment of malignant insulinomas and carcinoid tumors of the gastrointestinal tract,¹ gastrinomas have apparently not been treated with this drug to any great extent. To our knowledge only two cases have been reported, and the results attained were discouraging.^{2 , 3} The cases reported below concern successful treatment with streptozotocin of two patients with the Zollinger–Ellison syndrome without associated endocrinopathies.Case ReportsCase 1. A 56-year old man had a 15-year history of peptic ulcer and several earlier operations for recurrent ulcers. The diagnosis of the Zollinger–Ellison syndrome, suspected since 1968, was verified by serum . . .