Effect of Alloxan Diabetes on Reproduction in the Rat.

Abstract

The effects of alloxan diabetes on ovarian activity and pregnancy were studied in a series of 63 adult 9 rats. The development of permanent hyperglycemia resulted in an alteration of the normal estrous pattern, so that the intervals were greatly prolonged. Pregnancy progressed normally until about the 12th day following which the fetus died and was slowly absorbed. The placentas were retained and were delivered on the day of parturition. The adequate treatment of the alloxan diabetes by insulin resulted in normal pregnancies and live litters delivered at term.