OBSERVATIONS ON THE CARDIOVASCULAR—RENAL EFFECTS OF 9α-CHLOROHYDROCORTISONE ACETATE IN THE RAT1

Abstract

RECENT reports have indicated that the metabolic activity of hydrocortisone (compound F) may be considerably increased by halogen substitution in the 9α position. The original work demonstrated this with a chloro derivative (Fried and Sabo, 1953) and later studies extended the findings to the fluoro substituted compound (Fried and Sabo, 1954). A number of reports have already appeared substantiating and extending the original findings, especially those dealing with the chloro derivative (Callow et al., 1954; Liddle et al., 1954; Goldfien et al., 1954). It now appears that 9α-chlorohydrocortisone acetate exhibits a broad spectrum of enhanced activity extending from effects on carbohydrate metabolism to marked changes in electrolyte handling. In view of our observations concerning the blood pressure elevation which can be induced by compound F acetate in the rat (Friedman et al., 1952 and 1953), it seemed of interest to subject this new derivative to our screening test for cardiovascular-renal activity.