SYNTHESIS OF TETRA-N-PHENYLALKYLKANAMYCINS AND THEIR ANTIMICROBIAL ACTIVITIES

Abstract

Sixteen N, N', N", N'''-tetraphenylalkylkanamycins (hereafter simply written as tetra-N-phenylalkylkanamycins) were prepared, and their anti microbial activities in vitro were determined. They were less active against most strains tested than kanamycin. But one of them, tetra-N-4-chlorobenzyl kanamycin (XI) was slightly more active against Ps. aeruginosa than kanamycin. It was suggested that their activities relate with their lipophilicity. Seven of kanamycin derivatives were found active against kanamycin-resistant Escherichia coli and Staphylococcus aureus as well as sensitive strains.