Investigation of ketoacidurias by two-dimensional paper chromatography
- 1 July 1969
- journal article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 22 (4), 422-426
- https://doi.org/10.1136/jcp.22.4.422
Abstract
A simple paper chromatographic method was found to be effective for the study of phenylketonuria and tyrosyluria. It proved to be much more reliable than conventional tests for the detection of abnormal amounts of ketoacids in urine and was suitable and convenient for following the effects of dietary variations on the excretion of these compounds. Information obtained about ketones other than those of primary importance to the conditions studied included confirmation of the excretion of p-hydroxyphenylpyruvic acid in phenylketonuria. A modification of the method applicable to histidinaemia was devised.Keywords
This publication has 6 references indexed in Scilit:
- Recovery after dietary treatment of an infant with features of tyrosinosis.Archives of Disease in Childhood, 1969
- The detection of keto acids in biological fluids by two dimensional paper chromatography of their 2,4-dinitrophenylhydrazonesJournal of Chromatography A, 1968
- Paper chromatography of keto acid 2,4-dinitrophenylhydrazonesJournal of Chromatography A, 1967
- The tyrosine oxidation system of liver. IV. Studies on the inhibition of p-hydroxyphenylpyruvic acid oxidase by excess substrate.1959
- The Tyrosine Oxidation System of LiverPublished by Elsevier ,1959
- Über die Ausscheidung von Indolbrenztraubensäure im Urin von Gesunden und Patienten mit Föllingscher KrankheitKlinische Wochenschrift, 1956