Two cases of lactobezoar formation were seen in premature low-birth-weight infants fed a 24 cal/oz formula fortified with medium-chain triglycerides and glucose polymers given by continuous nasogastric infusion. Medical management included cessation of oral feedings and increased hydration and led to a rapid dissolution of the problem. The use of this preparation in small low-birth-weight infants is not recommended as an initial formula, and it should only be used when oral feedings have been well tolerated in a growing premature infant.