Autoimmune thyroiditis in manic-depressive patients treated with lithium
- 1 November 1985
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 142 (11), 1318-1321
- https://doi.org/10.1176/ajp.142.11.1318
Abstract
To explore whether lithium-induced hypothyroidism is related to an exacerbation of underlying autoimmune processes such as thyroiditis, the authors comprehensively assessed thyroid function in 16 manic-depressive patients. Each of the three patients who showed detectable titers of thyroid microsomal antibodies before treatment manifested a marked increase in antibody titer from 4 to 12 months after lithium treatment was begun. Thus, lithium-induced thyroid dysfunction may not only involve direct effects of the thyroid itself but also involve exacerbation of an underlying indolent autoimmune thyroiditis, possibly by causing shifts in T lymphocyte subpopulations.This publication has 4 references indexed in Scilit:
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- Adjuvant effects of lithium chloride on human mononuclear cells in suppressor-enriched and suppressor-depleted systemsImmunopharmacology, 1981
- Lithium: a Modulator of Cyclic AMP-Dependent Events in Lymphocytes?Science, 1979
- Thyroid Autoantibody Levels during Lithium TherapyNeuropsychobiology, 1978