THE EFFECT OF 5,6-DIMETHYLBENZIMIDAZOLE AND RELATED COMPOUNDS ON THE GROWTH OF LACTOBACILLUS LACTIS DORNER
- 1 November 1951
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 62 (5), 633-638
- https://doi.org/10.1128/jb.62.5.633-638.1951
Abstract
Vit. B12-requiring microorganisms (Lactobacillus lactis, L. lelchmannli and Euglena gracilis) are inhibited by l,2-dimethyl-4,5-diaminobenzene, 5,6-dimethylbenzimidazole, and several substituted benzimidazoles. The toxicity of the diamine is competitively antagonized by vit. B12 in studies with L. lactis. Such is not the case with the 5,6-dimethylbenzimidazole. When suboptimal levels of vit. B12 are supplied to L. lactis, several substituted anilines are capable of supporting optimal growth of this organism. This effect does not appear to be due to microbial synthesis of vit. B12.Keywords
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