Chiari I Malformation: Association With Seizures and Developmental Disabilities
- 1 February 1997
- journal article
- research article
- Published by SAGE Publications in Journal of Child Neurology
- Vol. 12 (2), 101-106
- https://doi.org/10.1177/088307389701200206
Abstract
Chiari I malformation, a congenital abnormality in which deformed cerebellar tonsils are displaced downward through the foramen magnum, commonly presents in patients with headache or symptoms of dysfunction of the cerebellum, brain stem, and cervical spinal cord. We report 11 children with Chiari I malformation who presented with seizures and developmental delay in motor or language function with or without autistic features. To our knowledge, an association between Chiari I malformation and seizures or neurodevelopmental deficits or both has not been previously reported. We believe that Chiari I malformation should not be considered an incidental finding in these patients, but may be a marker for subtle cerebral dysgenesis. Chiari I and II malformations may constitute a complex but continuous spectrum, related to the timing and severity of a shared underlying embryologic mechanism. ( J Child Neurol 1997;12:101-106).Keywords
This publication has 57 references indexed in Scilit:
- Hypoplasia of the Corpus Callosum: A Study of 445 Consecutive MRI ScansJournal of Child Neurology, 1994
- Lipomyeloschisis associated with thoracic syringomyelia and Chiari I malformationNeuroradiology, 1993
- Wide cavum septum pellucidum: A marker of disturbed brain developmentPediatric Neurology, 1990
- Chiari type I malformation in childrenThe Journal of Pediatrics, 1989
- Timing and positioning of reopening of the occluded spinal neurocele in the chick embryoJournal of Comparative Neurology, 1986
- Reduced number of brain cells in so‐called neural overgrowthThe Anatomical Record, 1985
- Descriptive studies of occlusion and reopening of the spinal canal of the early chick embryoThe Anatomical Record, 1984
- Neural tube occlusion precedes rapid brain enlargementJournal of Experimental Zoology, 1984
- Description of the occlusion of the spinal cord lumen in early human embryosThe Anatomical Record, 1982
- An experimental study of the development of the avian cloaca, with special reference to a mechanical factor in the growth of the allantoisJournal of Experimental Zoology, 1924