uPA+/+-SCID Mouse with Humanized Liver as a Model for In Vivo Metabolism of Exogenous Steroids: Methandienone as a Case Study
Open Access
- 1 October 2009
- journal article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 55 (10), 1783-1793
- https://doi.org/10.1373/clinchem.2008.119396
Abstract
Background: Adequate detection of designer steroids in the urine of athletes is still a challenge in doping control analysis and requires knowledge of steroid metabolism. In this study we investigated whether uPA+/+-SCID mice carrying functional primary human hepatocytes in their liver would provide a suitable alternative small animal model for the investigation of human steroid metabolism in vivo.Keywords
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