MACROGLOBULINEMIA WALDENSTRÖM AND MOTOR NEURON SYNDROME

Abstract

One patient with macroglobulinemia Waldenstrom developed a neurological disease which may be a previously unrecognized paramalignant phenomenon in this disorder. The clinical symptoms and signs indicated a motor neuron syndrome and autopsy revealed degeneration of ventral and lateral funicles in the spinal cord, loss of ventral motor neurons, degeneration of ventral nerve roots and muscular atrophy. The rather low incidence of macroglobulinemia and motor neuron disease suggests some casual relationship rather than a sporadic occurrence of the 2 disorders in the same patient.