Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans
- 1 January 1995
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 37 (1), 118-120
- https://doi.org/10.1002/ana.410370123
Abstract
As part of a community‐based study of Alzheimer's disease (AD) in the African‐American population age 65 and over, we have determined apolipoprotein E (Apo E) genotypes in 85 subjects (31 AD patients and 54 controls). The €4 allele of Apo E was strongly associated with AD in this population sample. The € allele frequency in AD patients was 40.3% compared with 13.9% in the control group, and 22.6% of the AD patients were homozygous for this allele compared with 3.7% of the control subjects (p = 0.01). This study extends the association of Apo E‐∈4 and AD to nonwhite populations and provides further evidence that the observed allelic association is biologically relevant.Keywords
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