Mineralocorticoid receptor blockade: new insights into the mechanism of action in patients with cardiovascular disease
Open Access
- 1 September 2003
- journal article
- review article
- Published by SAGE Publications in Journal of the Renin-Angiotensin-Aldosterone System
- Vol. 4 (3), 164-168
- https://doi.org/10.3317/jraas.2003.025
Abstract
Mineralocorticoid receptor (MR) blockade is effective in reducing total mortality and the incidence of heart failure in patients with systolic left ventricular dysfunction (SLVD) associated with chronic heart failure or post myocardial infarction.Keywords
This publication has 56 references indexed in Scilit:
- Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial InfarctionNew England Journal of Medicine, 2003
- Aldosterone in Congestive Heart FailureNew England Journal of Medicine, 2001
- Limitation of Excessive Extracellular Matrix Turnover May Contribute to Survival Benefit of Spironolactone Therapy in Patients With Congestive Heart FailureCirculation, 2000
- Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivoKidney International, 2000
- Spironolactone Increases Nitric Oxide Bioactivity, Improves Endothelial Vasodilator Dysfunction, and Suppresses Vascular Angiotensin I/Angiotensin II Conversion in Patients With Chronic Heart FailureCirculation, 2000
- The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart FailureNew England Journal of Medicine, 1999
- Aldosterone blunts the baroreflex response in manClinical Science, 1998
- Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patientsCardiovascular Research, 1997
- Chronic administration of aldosterone depresses baroreceptor reflex function in the dog.Hypertension, 1994
- Spironolactone in congestive heart failure refractory to high-dose loop diuretic and low-dose angiotensin-converting enzyme inhibitorThe American Journal of Cardiology, 1993