CARCINOMA OF THE ENDOMETRIUM .3. ANALYSIS OF 865 CASES OF ADENOCARCINOMA AND ADENOACANTHOMA

Abstract

Eight hundred sixty-five patients with confirmed adenocarcinoma of the endometrium were studied. Eight hundred eleven were followed up for at least 5 yr or until death, and 537 were followed up for 10 yr. The survival rate was 77.1% at 5 yr and 61.0% at 10 yr. Age at diagnosis was the single most important clinical determinant of survival. Tumor grade was an important predictor of the course of disease, and nuclear grade was a significantly more accurate indicator than was histologic grade. Stage and depth of invasion were also important predictors of survival. The 5-yr survival rate for black women was only 41.9%. Stage for stage and grade for grade, women undergoing hysterectomy alone and with radiation had similar survival rates. Adenoacanthoma had a better prognosis than did adenocarcinoma without squamous metaplasia; there were no deaths at 5 or 10 years in women diagnosed before age 50. The subtype of carcinoma was found to be a highly significant predictor of prognosis.