Organic Acid Movement Out of the Central Canal.

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Abstract
A method for perfusing the central canal of cats and rabbits is described. The reduction of concentration of PAH or CPR added to the perfusate is about the same as the reduction in concentration of added radio inulin. Reduction of CPR concentration is not influenced by probenecid or by the presence of another organic acid (PAH). The data are interpreted to indicate that the ependymal cells lining the central canal do not transport organic acids. It is suggested that the parallel reduction in concentration of inulin and added organic acid results from dilution of the perfusate.