Feline oncornavirus-associated cell membrane antigen: evidence for an immunologically crossreactive feline sarcoma virus-coded protein.
- 1 December 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (12), 5608-5612
- https://doi.org/10.1073/pnas.74.12.5608
Abstract
The feline oncornavirus-associated cell membrane antigen (FOCMA) acts as a target for natural immunosurveillance against tumor development in the cat. In the present study, mink and rat cells nonproductively transformed by feline sarcoma virus (FeSV) expressed FOCMA and 5''-terminal feline leukemia virus (FeLV) gag gene proteins, p15 and p12. Such cells lack detectable levels of other FeLV gag gene-coded proteins or the env gene product, gp 70. FOCMA, p15 and p12 antigen expression is initially in the form of an 80,000-100,000 MW precursor which, upon post-translational cleavage, gives rise to a 65,000 MW component that contains FOCMA and a 25,000 MW component containing p15 and p12. Feline lymphoma cells, including those from several tumors that lacked detectable levels of FeLV structural protein expression, were FOCMA-positive. These findings strongly suggest that FOCMA represents an FeSV-coded transformation specific protein and provide preliminary information regarding the position within the FeSV genome coding for its synthesis.This publication has 16 references indexed in Scilit:
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