Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men
- 8 September 2012
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 55 (12), 3341-3349
- https://doi.org/10.1007/s00125-012-2717-8
Abstract
Energy-dense diets that are high in fat are associated with a risk of metabolic diseases. The underlying molecular mechanisms could involve epigenetics, as recent data show altered DNA methylation of putative type 2 diabetes candidate genes in response to high-fat diets. We examined the effect of a short-term high-fat overfeeding (HFO) diet on genome-wide DNA methylation patterns in human skeletal muscle.Keywords
This publication has 39 references indexed in Scilit:
- Deoxyribonucleic Acid Methylation and Gene Expression of PPARGC1A in Human Muscle Is Influenced by High-Fat Overfeeding in a Birth-Weight-Dependent MannerJournal of Clinical Endocrinology & Metabolism, 2010
- DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specificHuman Molecular Genetics, 2009
- High fat diet-induced obesity modifies the methylation pattern of leptin promoter in ratsJournal of Physiology and Biochemistry, 2009
- TAF12 Recruits Gadd45a and the Nucleotide Excision Repair Complex to the Promoter of rRNA Genes Leading to Active DNA DemethylationMolecular Cell, 2009
- Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretionDiabetologia, 2008
- DNA methylation profiling of human chromosomes 6, 20 and 22Nature Genetics, 2006
- Maternal Genistein Alters Coat Color and Protects
A
vy
Mouse Offspring from Obesity by Modifying the Fetal EpigenomeEnvironmental Health Perspectives, 2006
- Epigenetic Transgenerational Actions of Endocrine Disruptors and Male FertilityScience, 2005
- Chromosomal Instability and Tumors Promoted by DNA HypomethylationScience, 2003
- Maternal epigenetics and methyl supplements affectagoutigene expression inAvy/amiceThe FASEB Journal, 1998