Tumorigenicity of Intraspecific Somatic Cell Hybrids in Nude Mice2

Abstract

Intraspecific somatic cell hybrids between normal mouse peripheral blood lymphocytes and a highly tumorigenic L-cell line (CI-1 D) produced tumors in nude mice. While the hybrid cells were tumorigenic, the length of time necessary for tumor appearance and the size of the tumor varied. Correlation between the growth rate of the parental and hybrid cells in vitro or their plating efficiency in methyl cellulose with the rapidity of tumor growth in vivo was not found.