Oxidation of Infused Acetate to Body Pool CO2

Abstract

Summary The rates of oxidation of acetate to C0₂ were estimated by using 1-C¹⁴ and 2-C¹⁴ labeled acetate and measuring both blood and expired C¹⁴0₂. Following 1-C¹⁴ labeled acetate infusion, the half life of blood and expired C¹⁴0₂ was about 76 minutes indicating a mean turnover time of acetate carboxyl to pool C0₂ of about 110 minutes. The half lives of 2-C¹⁴ labeled acetate were 135 minutes and 195 minutes respectively. The half life of the pool acetate was 1.2 minutes; turnover time 1.7 minutes; turnover rate 3.4 meq per hour and pool size 6.0 meq per sheep.