Monoclonal antibody reactive with the human epidermal-growth-factor receptor recognizes the blood-group-A antigen
- 1 November 1983
- journal article
- research article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 3 (11), 1045-1052
- https://doi.org/10.1007/bf01121031
Abstract
The hybridoma antibody TL5, which precipitates the EGF receptor from the human epidermoid carcinoma cell line A431, has been shown to recognize the blood-group-A carbohydrate structure. This conclusion has been reached from studies of (a) the binding of the antibody to glycoproteins and haemagglutination of erythrocytes with known blood-group-antigen activities and (b) the inhibition of binding of the antibody to a radiolabelled blood-group-A-active glycoprotein by structurally defined oligosaccharides.This publication has 39 references indexed in Scilit:
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