Dependence of H2O2 Formation by Rat Heart Mitochondria on Substrate Availability and Donor Age
- 1 January 1997
- journal article
- Published by Springer Nature in Journal of Bioenergetics and Biomembranes
- Vol. 29 (1), 89-95
- https://doi.org/10.1023/a:1022420007908
Abstract
We have examined the substrate specificity and inhibitor sensitivity of H2O2 formation by rat heart mitochondria. Active H2O2production requires both a high fractional reduction of Complex I...Keywords
This publication has 25 references indexed in Scilit:
- Multiplet structure of 13C NMR signal from glutamate and direct detection of tricarboxylic acid (TCA) cycle intermediatesMagnetic Resonance in Medicine, 1996
- Hydroxyl Radical Generation During Mitochondrial Electron-Transfer and the Formation of 8-Hydroxydesoxyguanosine in Mitochondrial-DNAArchives of Biochemistry and Biophysics, 1995
- Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouseMechanisms of Ageing and Development, 1994
- Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brainAnnals of Neurology, 1993
- Hydrogen peroxide production by mitochondria may be a biomarker of agingMechanisms of Ageing and Development, 1991
- MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASESThe Lancet, 1989
- Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondriaArchives of Biochemistry and Biophysics, 1985
- Mitochondrial role in cell agingExperimental Gerontology, 1980
- Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady stateThe Journal of Membrane Biology, 1979
- Do Mitochondria Produce Oxygen Radicals in vivo?European Journal of Biochemistry, 1978