Association of Blood Pressure With Blood Viscosity in American Indians
- 1 April 2005
- journal article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 45 (4), 625-630
- https://doi.org/10.1161/01.hyp.0000157526.07977.ec
Abstract
Abnormalities in whole blood viscosity (WBV) have been implicated in hypertension. This study analyzes relations between WBV and blood pressure in the Strong Heart Study population of American Indians. We examined 676 participants (489 women, age 62±7 years) without prevalent cardiovascular disease or use of antihypertensive medications, digoxin, or aspirin. WBV was calculated from hematocrit and plasma protein concentration, at a shear rate of 208 seconds −1 , by a validated equation. Forty eight percent of participants were obese, 43% had diabetes, 19% had hypertension, and 30% were current smokers. WBV was higher in men, smokers, and participants with central obesity, but it was not associated with hypertension or diabetes, even accounting for confounders. After adjusting for gender, age, center, smoking, obesity, diabetes, and plasma creatinine, WBV was negatively related to pulse pressure (β=−0.13; P P R =0.63; P R =0.42; P <0.0001). Thus, under normal physiological conditions, in vivo WBV is negatively related pulse pressure. In contrast, the presence of arterial hypertension makes this relation less evident.Keywords
This publication has 23 references indexed in Scilit:
- Intra-abdominal obesity and metabolic risk factors: a study of young adultsInternational Journal of Obesity, 2003
- Executive SummaryObesity Research, 1998
- Corresponding Pulse Pressure and Arterial Compliance Variations during Ambulatory MonitoringAnnals of the New York Academy of Sciences, 1996
- Body fat distribution and whole blood viscosity in a sample of Italian men and womenThe American Journal of Cardiology, 1994
- Sex differences in cardiac adaptation to isolated systolic hypertensionThe American Journal of Cardiology, 1993
- Increase in erythrocyte disaggregation shear stress in hypertension.Hypertension, 1992
- Increased whole blood viscosity combined with decreased erythrocyte fluidity in untreated patients with essential hypertensionJournal of Internal Medicine, 1990
- Elevated blood viscosity in patients with borderline essential hypertension.Hypertension, 1983
- Changes in Blood Viscosity Accompanying the Response to Prazosin in Patients with Essential HypertensionJournal of Cardiovascular Pharmacology, 1979
- Hematocrit, plasma protein, plasma volume, and viscosity in early hypertensive diseaseAmerican Heart Journal, 1966