Induction of IgG secretion in a human B cell clone with recombinant IL 2.
- 1 May 1985
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 134 (5), 3104-3107
- https://doi.org/10.4049/jimmunol.134.5.3104
Abstract
A human B cell clone (SGB3) responsive to IL 2 was established. Both recombinant IL 2 and B cell differentiation factor (BCDF) induced IgG secretion in SGB3 cells in a dose-dependent manner, but IL 2 did not affect the proliferation of SGB3 cells. FACS analysis showed that SGB3 cells expressed Tac antigen and anti-Tac antibody inhibited IL 2-induced IgG secretion without any inhibitory effect on BCDF-induced IgG secretion. These results showed that IL 2 could directly act on B cells and provide a differentiation signal through IL 2 receptors distinct from BCDF receptors. Physiologic relevance of IL 2 in the antibody response was discussed.This publication has 1 reference indexed in Scilit:
- T cell-replacing factor- (TRF) induced IgG secretion in a human B blastoid cell line and demonstration of acceptors for TRF.The Journal of Immunology, 1981