Lophotoxin: a Novel Neuromuscular Toxin from Pacific Sea Whips of the Genus Lophogorgia
- 26 June 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 212 (4502), 1512-1514
- https://doi.org/10.1126/science.6112796
Abstract
A new neuromuscular toxin, lophotoxin, has been isolated from several pacific gorgonians of the genus Lophogorgia. The structure of lophotoxin was deduced by combined spectrochemical methods, and belongs to the well-known cembrene class of diterpenoid molecules. Lophotoxin contains furanoaldehyde and alpha, beta-epoxy-gamma-lactone functional groups, in sharp contrast to the cationic ammonium functional groups of the established neurotoxins.This publication has 9 references indexed in Scilit:
- Chemical Defense Mechanisms on the Great Barrier Reef, AustraliaScience, 1981
- Cyclic monoterpenoid feeding deterrents from the red marine alga Ochtodes crockeriThe Journal of Organic Chemistry, 1980
- An Investigation of the Antitumor Activity of Micromelum integerrimum (Rutaceae)Journal of Natural Products, 1979
- A total synthesis of dl-ceruleninJournal of the American Chemical Society, 1979
- Pukalide, a furanocembranolide from the soft coral Sinularia abruptaTetrahedron, 1975
- Carbon-13 magnetic resonance study of terpenoids. I. Application of heteronuclear selective decoupling experiments to the spectral assignments of nonproton-bearing carbon-13 resonances of a germacranolide, melampodinThe Journal of Organic Chemistry, 1973
- New methods for the oxidation of aldehydes to carboxylic acids and estersJournal of the American Chemical Society, 1968
- Picrotoxinin and Related SubstancesChemical Reviews, 1967
- Sesquiterpenes of neolitsea zeylanica merr.—ITetrahedron, 1967