Association studies of the CT repeat polymorphism in the 5′ upstream region of the cholecystokinin B receptor gene with panic disorder and schizophrenia in Japanese subjects
- 7 November 2001
- journal article
- research article
- Published by Wiley in American Journal of Medical Genetics
- Vol. 105 (8), 779-782
- https://doi.org/10.1002/ajmg.10043
Abstract
The tetrapeptide of cholecystokinin (CCK), CCK‐4, is known to induce panic attacks in human subjects, while CCK‐8 is reported to have a therapeutic effect on schizophrenia symptoms. Recently, we have identified a novel microsatellite polymorphism in the 5′ upstream region of the CCK gene and shown a significant association between this polymorphism and panic disorder. In this study, we have investigated the CCK‐B receptor (CCKBR) gene, which is the main constituent of the CCK receptor in the CNS. Recently, a dinucleotide repeat, (CT)n, in the 5′ regulatory region of the CCKBR gene was reported to be associated with panic disorder in Canadian samples. To evaluate an association of the CT repeat with panic disorder and schizophrenia, we genotyped 71 subjects with panic disorder, 154 schizophrenics and 199 controls. However, no evidence of allelic association was found between the polymorphic repeat of the CCKBR gene and either panic disorder or schizophrenia (P = 0.186 and 0.987, respectively). Together with the negative reports on association analyses using other polymorphisms of the CCKBR gene and Japanese samples, the present results exclude a major genetic contribution of the CCKBR gene to susceptibilities to panic disorder and schizophrenia in Japanese cohorts.Keywords
This publication has 19 references indexed in Scilit:
- Association studies of the cholecystokinin B receptor and A2a adenosine receptor genes in panic disorderJournal of Neural Transmission, 2001
- Identification of a compound short tandem repeat stretch in the 5′-upstream region of the cholecystokinin gene, and its association with panic disorder but not with schizophreniaMolecular Psychiatry, 2001
- No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorderMolecular Psychiatry, 2000
- Investigation of Genetic Risk Factors Associated with AlcoholismAlcohol, Clinical and Experimental Research, 1996
- Missense mutation of the cholecystokinin B receptor gene: Lack of association with panic disorderAmerican Journal of Medical Genetics, 1996
- Monte Carlo tests for associations between disease and alleles at highly polymorphic lociAnnals of Human Genetics, 1995
- Family genetic studies of panic disorderJournal of Psychiatric Research, 1993
- A twin study of DSM‐III‐R anxiety disordersActa Psychiatrica Scandinavica, 1993
- Cholecystokinin-dopamine intearctionsTrends in Pharmacological Sciences, 1991
- Evidence for coexistence of dopamine and CCK in meso-limbic neuronesNature, 1980