Helicobacter pylorieradication and associated changes in the gastric mucosa
- 1 October 2005
- journal article
- review article
- Published by Taylor & Francis in Expert Review of Anti-infective Therapy
- Vol. 3 (5), 757-764
- https://doi.org/10.1586/14787210.3.5.757
Abstract
Persistent Helicobacter pylori infection contributes towards the development of chronic gastritis. To clarify the changes in chronic gastritis as a precursor of gastric cancer secondary to H. pylori eradication is an important issue, as it has significant implications for reducing the risk of gastric cancer. Studies published to date, however, are far from consistent with regard to the morphologic changes reported following H. pylori eradication. Of these, some papers reported improvement in gastric atrophy or intestinal metaplasia, versus others reporting no improvement, with the majority of papers published after 2000 reporting improvement in these end points. The inconsistent results concerning the impact of H. pylori eradication on gastric atrophy could be due to the inconsistency of the diagnostic criteria employed for evaluation of the morphology, confounded by the difficulties involved in evaluating atrophic changes in the gastric mucosa. While adherence to the Updated Sydney System available for evaluation of gastritis is primarily required worldwide to ensure consistency in evaluating gastritis, long-term research into the morphologic changes associated with H. pylori eradication is also required to explore strategies for the prevention of gastric cancer with H. pylori eradication.Keywords
This publication has 31 references indexed in Scilit:
- Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of ChinaJAMA, 2004
- Pathogenesis of Pre-Neoplastic Lesions of the Stomach: Targets for PreventionDigestive Diseases, 2004
- Sensitivity of biopsy site in evaluating regression of gastric atrophy after Helicobacter pylori eradication treatmentAlimentary Pharmacology & Therapeutics, 2002
- Helicobacter pyloriInfection and the Development of Gastric CancerNew England Journal of Medicine, 2001
- Classification and Grading of GastritisThe American Journal of Surgical Pathology, 1996
- Long-Term Course and Consequences ofHelicobacter pylorigastritis Results of a 32-Year Follow-up StudyScandinavian Journal of Gastroenterology, 1996
- Long-term sequelae of Helicobacter pylori gastritisThe Lancet, 1995
- Effect of eradication of Helicobacter pylori on gastric epithelial cell proliferationAlimentary Pharmacology & Therapeutics, 1994
- Gastric cancer risk in chronic atrophic gastritis: Statistical calculations of cross‐sectional dataInternational Journal of Cancer, 1985
- The Sequelae and Course of Chronic Gastritis during a 30- to 34-Year Bioptic Follow-up StudyScandinavian Journal of Gastroenterology, 1985