THE CONTRIBUTORY RÔLE OF THE AFFERENT NERVOUS FACTOR IN EXPERIMENTAL SHOCK: SUBLETHAL HEMORRHAGE AND SCIATIC NERVE STIMULATION

Abstract

Electrical stimulation of the sciatic nerves produced a pressor effect in sublethally hemorrhaged dogs. Nevertheless, the residual blood vol. at the 50% mortality point (69.0 [plus or minus] 2.5 ml./kg.) is significantly higher than the corresponding value in the simple hemorrhage series (59.1 [plus or minus] 2.9 ml./kg.). Evidence is presented which indicates that the clinical manifestations of dogs subjected to sublethal hemorrhage plus afferent stimulation are modified toward those shown by the traumatized animals: early tachycardia exceeding 200 beats/ min., relatively high mean blood pressure and early central nervous depression. The changes of serum protein concs. and hematocrit values are also less than the corresponding changes in the simple hemorrhage series.