Mutagenicity screening of twenty‐five cosmetic ingredients with the salmonella/microsome test

Abstract

The possible mutagenic activity of 25 cosmetic ingredients was investigated using the Salmonella histidine auxotrophs hisTA98, hisTA100, hisTA1535, hisTA1537 and hisTA1538. All 25 cosmetic ingredients were subjected to the spot test, a qualitative form of the Salmonella/microsome test. Of the 25 cosmetic ingredients, 9 demonstrated potential mutagenicity in the spot testing and were further examined in plate incorporation tests, a quantitative form of the Salmonella/microsome test. Only 1 tested cosmetic ingredient, DEA [dehydroepiandrosterone] laureth sulfate, gave positive mutagenic results in the plate incorporation test. [This study could be applicable to humans.].