Rapid Determination of Six Low Molecular Carbonyl Compounds in Tobacco Smoke by the APCI-MS/MS Coupled to Data Mining
Open Access
- 1 January 2017
- journal article
- research article
- Published by Hindawi Limited in Journal of Analytical Methods in Chemistry
- Vol. 2017, 1-7
- https://doi.org/10.1155/2017/8260860
Abstract
A simple method was established for the rapid determination of low molecular carbonyl compounds by the combination of atmospheric pressure chemical ionization tandem mass spectrometry (APCI-MS/MS) and data mining. The ionization was carried out in positive mode, and six low molecular carbonyl compounds of acrolein, acetone, propionaldehyde, crotonaldehyde, butanone, and butyraldehyde were analyzed by both full scan mode and daughter scan mode. To overcome the quantitative difficulties from isomer of acetone/propionaldehyde and butanone/butyraldehyde, the quantitation procedure was performed with the characteristic ion of [CH3O]+ under CID energy of 5 and 15 eV. Subsequently, the established method was successfully applied to analysis of six low molecular carbonyl compounds in tobacco smoke with analytical period less than four minutes. The contents of acrolein, acetone, propionaldehyde, crotonaldehyde, butanone, and butyraldehyde for a cigarette were about , , , , , and μg/cig, respectively. The experimental results indicated that the established method had the potential application in rapid determination of low molecular carbonyl compounds.
Keywords
Funding Information
- National Natural Science Foundation of China (21675173)
This publication has 27 references indexed in Scilit:
- Levels and Health Risk of Carbonyl Compounds in Air of the Library in Guangzhou, South ChinaAerosol and Air Quality Research, 2016
- Development of a sampling method for carbonyl compounds released due to the use of electronic cigarettes and quantitation of their conversion from liquid to aerosolJournal of Chromatography A, 2016
- Extraction and Quantitation of Ketones and Aldehydes from Mammalian Cells Using Fluorous Tagging and Capillary LC-MSAnalytical Chemistry, 2015
- Derivatization techniques for determination of carbonyls in airTrAC Trends in Analytical Chemistry, 2015
- From physical chemistry to mass spectrometry to government lab manager in half a centuryMass Spectrometry Reviews, 2014
- Micro solid‐phase derivatization analysis of low‐molecular mass aldehydes in treated water by micellar electrokinetic chromatographyElectrophoresis, 2013
- Health Risk Assessment of Petrol Station Workers in the Inner City of Bangkok, Thailand, to the Exposure to BTEX and Carbonyl Compounds by InhalationHuman and Ecological Risk Assessment: An International Journal, 2012
- Simultaneous Quantification of 1,N2-Propano-2′-deoxyguanosine Adducts Derived from Acrolein and Crotonaldehyde in Human Placenta and Leukocytes by Isotope Dilution Nanoflow LC Nanospray Ionization Tandem Mass SpectrometryAnalytical Chemistry, 2009
- Reducing emissions of carbonyl compounds and regulated harmful matters from a heavy-duty diesel engine fueled with paraffinic/biodiesel blends at one low load steady-state conditionAtmospheric Environment, 2009
- Determination of 11 Low-Molecular-Weight Carbonyl Compounds in Marine Algae by High-Performance Liquid ChromatographyJournal of Chromatographic Science, 2006