Clastogen-induced chromosomal breakage as a marker for first trimester prenatal diagnosis of Fanconi anemia
- 1 May 1986
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 73 (1), 86-88
- https://doi.org/10.1007/bf00292671
Abstract
Using cultured trophoblast cells obtained by chorionic villus biopsy, we diagnosed Fanconi anemia (FA) in two pregnancies and excluded it in eight pregnancies at risk for the syndrome. Baseline chromosomal breakage and breakage induced by diepoxybutane (DEB) were analyzed. Increased breakage was used as a marker for the syndrome. Our results were unambiguous and provide a reliable method for prenatal detection of FA in the first trimester of pregnancy.Keywords
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