Aging dependent nucleolar and chromatin changes in cultivated fibroblasts
- 1 January 1983
- journal article
- research article
- Published by Wiley in Cell Biology International Reports
- Vol. 7 (1), 61-71
- https://doi.org/10.1016/0309-1651(83)90105-4
Abstract
Adult fibroblasts already at low population doubling level (PDL) have a significant percentage of cells with modified chromatin was compared to embryonic cells where altered chromatin is seen only at high PDL. In fibroblast populations from a patient with Werner''s syndrome, the percentage of cells with both altered chromatin and nucleoli was much higher than in the control cultures from normal donors. The data show for the first time nucleoprotein changes in cells from donors with an aging syndrome and reinforce the concept that serial replication of fibroblasts in vitro causes lesions identical to those of aging in vivo.This publication has 11 references indexed in Scilit:
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