The influence of chronic pain on the analgesic effects of the α2‐adrenoceptor agonist, xylazine, in sheep
- 28 June 1991
- journal article
- Published by Wiley in Journal of Veterinary Pharmacology and Therapeutics
- Vol. 14 (2), 141-144
- https://doi.org/10.1111/j.1365-2885.1991.tb00815.x
Abstract
A comparison of the analgesic potency of the alpha 2-adrenoceptor agonist, xylazine, in control healthy sheep and sheep suffering chronic pain from footrot, indicated that the analgesic effectiveness of xylazine was significantly reduced in the animals experiencing chronic pain. This was measured by recording the threshold to a mechanically applied pressure stimulus. Furthermore, when the condition was apparently resolved, by conventional treatment over a period of 2 to 3 weeks, the decreased analgesic effectiveness of the alpha 2-agonist was still apparent although the animals were clinically cured of the footrot.Keywords
This publication has 10 references indexed in Scilit:
- Temporal relationships between changes in phantom limb pain intensity and changes in surface electromyogram of the residual limbInternational Journal of Psychophysiology, 1992
- Receptor changes in the spinal cord of sheep associated with exposure to chronic painPain, 1990
- The effect of chronic clinical pain on thermal and mechanical thresholds in sheepPain, 1989
- Phantom limb pain in amputees during the first 12 months following limb amputation, after preoperative lumbar epidural blockadePain, 1988
- Postoperative orthopaedic pain — the effect of opiate premedication and local anaesthetic blocksPain, 1988
- Antinociceptive actions of intravenous a2-adrenoceptor agonists in sheepJournal of Veterinary Pharmacology and Therapeutics, 1987
- Techniques for comparison of thermal and mechanical nociceptive stimuli in the sheepJournal of Pharmacological Methods, 1987
- Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent inputNature, 1987
- Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the ratJournal of Neuroscience, 1986
- Evidence for a central component of post-injury pain hypersensitivityNature, 1983