Biological Activity and Metabolism of d, 1-O-Heterobiotin in the Chick.

Abstract

D,l-O-Heterobiotin has biotin-like activity for the chick. Levels of 20 [gamma]/100 g. of purified biotin-deficient basal ration give complete protection against dermatitis and some growth response. The growth activity of the oxygen analog varies inversely with the level fed and growth comparable to that on an adequate biotin diet was not obtained. d,l-O-Hetero-biotin can be detected in the liver and muscle tissue of chicks fed high amts. of this compound.