Clonidine: Attenuation of sedative action by facilitated central noradrenergic neurotransmission
- 1 March 1980
- journal article
- research article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 47 (1), 29-39
- https://doi.org/10.1007/bf01256637
Abstract
Administration of clonidine, 0.05 mg/kg i.p. to mice 30 min before trial significantly depressed the exploration of a Y-maze. This effect was completely antagonized by l-amphetamine, 0.75 mg/kg i.p., given 10 min before trial, which by itself did not change the behaviour studied. The clonidine-induced behavioural depression also appeared reduced after pre-treatment with desipramine (10 mg/kg i.p., 30 min before clonidine) which, like l-amphetamine, by itself was inactive. The above treatment with clonidine significantly reduced the accumulation of dopa after inhibition of central aromatic L-aminp acid decarboxylase both in the noradrenaline (NA) rich neocortex and the dopamine-rich corpus striatum, whereas the dopa accumulation in the limbic brain regions was not significantly affected. l-Amphetamine, 0.75 mg/kg i.p., did not by itself significantly affect the dopa accumulation, but reduced the clonidine-induced effects. The results are compatible with the notion that the depression of exploratory behaviour by clonidine is related to impaired central NA-neurotransmission and rule out the possibility that it is due to activation of central post-synaptic NA-(α-)receptors.This publication has 44 references indexed in Scilit:
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