Gastric hemorrhage induced by nonnarcotic analgetic agents in dogs
- 1 March 1966
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 7 (2), 239-249
- https://doi.org/10.1002/cpt196672239
Abstract
The effect of various nonnarcotic analgetic agents in producing gastric hemorrhage has been investigated in Pavlov‐pouch dogs. Of the compounds tested, only aspirin in suspension at pH 3.0 produced extensive bleeding. The same drug in solution, as well as salicylic acid, salicylamide, methylsalicylate, and acetaminophen, produced no significant effect. Intravenous aspirin in high doses failed to cause gastric effects.This publication has 5 references indexed in Scilit:
- Gastric Mucosal Injury by Fatty and Acetylsalicylic AcidsGastroenterology, 1964
- Topical Action of Salicylates in Gastrointestinal Erosion and HemorrhageGastroenterology, 1963
- A COMPARISON OF GASTROINTESTINAL ABSORPTION RATES OF PLAIN AND BUFFERED ACETYLSALICYCLIC ACID1962
- Aspirin and gastric bleedingAmerican Journal Of Medicine, 1961
- SALICYLATE TOXICITY: THE PROBABLE MECHANISM OF ITS ACTIONAnnals of Internal Medicine, 1946