Sensitivity of Mycobacterium leprae to Low Levels of 4,4-Diaminodiphenyl Sulfone.
- 1 July 1966
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 122 (3), 893-896
- https://doi.org/10.3181/00379727-122-31282
Abstract
Summary 1. The activity against M yco-bacterium leprae of 4,4-diaminodiphenyl sul-fone (DDS) was tested in mice by feeding a series of diets containing the drug in concentrations ranging from 0.03 to 0.00001%. Multiplication of M. leprae was completely suppressed at all levels. 2. The lowest DDS intake was a hundred times less that the least amount required to produce chemically detectable amounts in the blood (0.2 to 0.3 μg/ml).This publication has 5 references indexed in Scilit:
- Studies on a Dihydrotriazine and a Sulfone, Alone and in Combination, against Plasmodium berghei in MiceThe American Journal of Tropical Medicine and Hygiene, 1965
- Mycobacterium leprae in Mice: Minimal Infectious Dose, Relationship Between Staining Quality and Infectivity, and Effect of CortisoneJournal of Bacteriology, 1965
- Effect of Several Anti-Leprosy Drugs on Multiplication of Human Leprosy Bacilli in Foot-Pads of MiceExperimental Biology and Medicine, 1962
- THE EXPERIMENTAL DISEASE THAT FOLLOWS THE INJECTION OF HUMAN LEPROSY BACILLI INTO FOOT-PADS OF MICEThe Journal of Experimental Medicine, 1960
- Radioactive Tracer Studies on Uptake of Diamino-diphenyl-sulphone by Leprosy PatientsExperimental Biology and Medicine, 1957