Chromosomal localization of the human oncogene ERBA2
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 43 (3-4), 150-153
- https://doi.org/10.1159/000132313
Abstract
The human ERBA2 gene has been mapped to chromosome 17q21.3 by in situ hybridization. A second hybridization site at 17q25 was greatly reduced by high stringency washes, indicating the presence of an additional member of the ERBA2 family at this location. Southern blot hybridization using identical conditions did not reveal additional bands, and hybridizations done at sufficiently low stringency to reveal further bands produced multiple bands rather than the single additional band expected from the in situ results. Direct comparisons of in situ and Southern hybridizations should therefore be treated with caution. The location of these two oncogenes may be significant in cases of acute promyelocytic leukaemia and acute nonlymphocytic leukaemia.This publication has 1 reference indexed in Scilit: