A test of the effects of pregnenolone methyl ether on subjective feelings of B-29 crews after a twelve-hour mission.

Abstract

Members of 7 B-29 crews received PME (experimental = 51) or a placebo (controls = 49) and took a group of psychological tests measuring manifest irritability, anxiety, and fatigue reactions, after a long (15-18 hours) over-water training mission. The tests were administered both before the drug administration (immediately upon landing) and after unloading the planes (which followed drug administration). Although there were significant pre-test and post-test differences for each group, there were no significant inter-group differences. "This study does not support the use of PME for the alleviation of depression, irritability and anxiety feelings of crew members. ".