THE CUTANEOUS REACTION TO SOLUBLE ANTIGEN-ANTIBODY COMPLEXES
Open Access
- 1 November 1958
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 108 (5), 591-604
- https://doi.org/10.1084/jem.108.5.591
Abstract
The in vivo activity of soluble antigen-antibody complexes was tested by a single intradermal injection in rabbits. Skin reactions were obtained marked by erythema, induration, and occasionally hemorrhage and necrosis. Microscopically, diffuse inflammation and occasional vascular necrosis could be found at all dosages. This indicates that soluble antigen-antibody complexes are phlogogenic and provides support for the suggestion that complexes are responsible for the lesions seen in serum sickness.Keywords
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