Effect of pH and proton buffer on oscillations of ion fluxes in rat erythrocytes

Abstract
The pH-dependence of ionophore-induced oscillations of transmembrane H+ and K+ fluxes in rat erythrocytes was studied. The oscillations apparently are strongly depressed at pH 6.9 and > 7.3. Proton buffers of different nature (Tris/HCl, Mops and glycylglycine) are shown to effectively inhibit the oscillatory process. The significance of H+ concentration in unstirred layers adjacent to the membrane in the mechanism of oscillations is suggested.