Release by Electrical Stimulation of Endogenous Glutamate, γ‐Aminobutyric Acid, and Other Amino Acids from Slices of the Rat Medulla Oblongata
- 1 January 1989
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 52 (1), 261-267
- https://doi.org/10.1111/j.1471-4159.1989.tb10926.x
Abstract
Evidence was obtained for the release of amino acids by electrical stimulation of slices of regions of the rat medulla oblongata: rostral ventrolateral, caudal ventrolateral, and caudal dorsomedial. There was a Ca2+-dependent, tetrodotoxin-sensitive increase in the efflux of aspartate, glutamate, .gamma.-aminobutyric acid (GABA), glycine, and .beta.-alanine in all regions examined. There were distinct regional differences in the relative amounts of amino acids released. These results provide evidence for the possible neurotransmitter role of aspartate, glutamate, GABA, glycine, and .beta.-alanine in these regions of the rat medulla oblongata.Keywords
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