Synthesis ofCis-1-[(2-Hydroxymethyl) Cyclopentyl]Uridine and Determination of its Conformation by X-Ray Crystallography and Ami Theoretical Calculations
- 1 June 1996
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 15 (6), 1179-1187
- https://doi.org/10.1080/07328319608007386
Abstract
Abtract:The title compound 1 was prepared from racemic cis-2-hydroxymethylcyclo pentylamine, constructing the heterocyclic base in a two-step procedure (64 % yield). The crystal structure of the compound was determined and its conformation was studied using AMI theoretical calculations. The calculated low-energy conformations were similar to those reported for several other nucleoside analogues, and one of them closely corresponded to the X-ray structure.Keywords
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