Lack of myocardial perfusion immediately after successful thrombolysis. A predictor of poor recovery of left ventricular function in anterior myocardial infarction.
- 1 May 1992
- journal article
- abstracts
- Published by Wolters Kluwer Health in Circulation
- Vol. 85 (5), 1699-1705
- https://doi.org/10.1161/01.cir.85.5.1699
Abstract
BACKGROUNDWe investigated myocardial perfusion dynamics after thrombolysis and its clinical implications.METHODS AND RESULTSWe studied 39 patients with acute anterior myocardial infarction (AMI). Myocardial contrast echocardiography (MCE) was performed before and immediately after successful reflow with intracoronary injection of sonicated Ioxaglate. The average segmental score by two-dimensional echocardiography (graded 0, normal, to 3, akinetic/dyskinetic) and global ejection fraction (left ventricular ejection fraction, LVEF%) by left ventriculography were measured at 1 day and at 4 weeks after reflow. Hypokinesis in the infarct region was assessed by the centerline method and expressed in terms of standard deviations (regional wall motion [RWM]: SD/chord) of normal. Immediately after reflow, 30 of 39 patients (group A) showed significant contrast enhancement within the risk area. The other nine patients (23%, group B), however, showed the residual contrast defect in the risk area (myocardial no reflow...Keywords
This publication has 8 references indexed in Scilit:
- Myocardial risk area and peak gray level measurement by contrast echocardiography: Effect of microbubble size and concentration, injection rate, and coronary vasodilationAmerican Heart Journal, 1988
- Analysis of reported randomized trials of streptokinase therapy for acute myocardial infarction in the 1980sThe American Journal of Cardiology, 1987
- Salvage of ischaemic myocardium by reperfusion: importance of collateral blood flow and myocardial oxygen demand during occlusionCardiovascular Research, 1986
- Contrast echocardiography in acute myocardial ischemia. II. The effect of site of injection of contrast agent on the estimation of area at risk for necrosis after coronary occlusionJournal of the American College of Cardiology, 1985
- Scintigraphic evidence of the “No reflow” phenomenon in human beings after coronary thrombolysisJournal of the American College of Cardiology, 1985
- Verification of myocardial contrast two-dimensional echocardiographic assessment of perfusion defects in ischemic myocardiumJournal of the American College of Cardiology, 1984
- Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog.Circulation, 1983
- The “No-Reflow” Phenomenon after Temporary Coronary Occlusion in the DogJournal of Clinical Investigation, 1974