Release Kinetics of Indomethacin from Polymeric Matrices
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 13 (8), 1399-1408
- https://doi.org/10.3109/03639048709068382
Abstract
Polymeric matrices containing three different concentrations of indomethacin 1, 2 and 4% preparations were prepared. The release kinetics of indomethacin from matrices followed Higuchi equation. The effective diffusivity of indomethacin (Dm) was 1.32 × 10−7 +7.4% cm2/sec. The amount released in 24 hours 2 from 10 cm2 matrices with three different concentrations of indomethacin, were 12.0, 18.6 and 25.0 mg respectively. These matrices may potentially be developed as a transdermal therapeutic system.This publication has 8 references indexed in Scilit:
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