The cardiospecificity of the third-generation cTnT assay after exercise-induced muscle damage
- 1 April 2002
- journal article
- basic sciences
- Published by Wolters Kluwer Health in Medicine & Science in Sports & Exercise
- Vol. 34 (4), 651-654
- https://doi.org/10.1097/00005768-200204000-00014
Abstract
SHAVE, R., E. DAWSON, G. WHYTE, K. GEORGE, D. BALL, P. COLLINSON, and D. GAZE. The cardiospecificity of the third-generation cTnT assay after exercise-induced muscle damage. Med. Sci. Sports Exerc., Vol. 34, No. 4, pp. 651–654, 2002. Purpose The purpose of the present study was to examine the cardiospecificity of cTnI and the new third-generation cTnT assay, in the presence of exercise-induced muscle damage in highly trained individuals, and to examine the impact of a maximal-ramping treadmill test on cardiac function. Methods Eight highly trained male triathletes (mean ± SD; age: 29 ± 9 yr; height: 1.79 ± 0.10 m; body mass: 77 ± 10 kg; V̇O2max: 67.4 ± 6.3 mL·kg−1·min−1) completed two bouts of exercise. On the first occasion, subjects completed a maximal-ramping treadmill test. On a separate occasion, the subjects completed 30 min of downhill running (15% gradient) at a speed equivalent to 70% of maximal running velocity attained during the maximal-ramping treadmill test. All subjects were assessed using ECG, echocardiography, and blood analysis. Measurements were taken at rest, immediately after, and 48 h postexercise for each bout of exercise. Echocardiographic analysis was used to determine left ventricular systolic and diastolic function. Blood samples were analyzed for markers of myocyte damage. Results Echocardiographic results indicated normal left ventricular function before and after both exercise bouts. Total CK and CKMB were significantly elevated 48 h after the downhill run. cTnT and cTnI were not elevated at any stage of the study. Conclusions Neither the maximal-ramping treadmill test nor the 30-min downhill run produced cardiac dysfunction or myocardial damage in young, healthy trained subjects. The elevated total CK and CKMB within the downhill study are noncardiac in origin as demonstrated by the lack of cTnT and cTnI. The cTnI and new third-generation cTnT assays may be used to detect cardiac damage in the presence of elevated total CK and CKMB associated with exercise-induced skeletal muscle damage.Keywords
This publication has 14 references indexed in Scilit:
- Cardiac troponin T and I, electrocardiographic wall motion analyses, and ejection fractions in athletes participating in the Hawaii Ironman TriathlonThe American Journal of Cardiology, 1999
- Changes in Skeletal and Cardiac Muscle Enzymes during the Scottish Coast to Coast TriathlonScottish Medical Journal, 1999
- Use of recombinant human cardiac Troponin T for standardization of third generation Troponin T methodsScandinavian Journal of Clinical and Laboratory Investigation, 1999
- Evidence of Myocardial Injury During Prolonged Strenuous Exercise**This study was supported in part by Boehringer Mannheim Corporation, Indianapolis, Indiana.The American Journal of Cardiology, 1996
- Serum Cardiac Troponin T After Repeated Endurance Exercise EventsInternational Journal of Sports Medicine, 1996
- Cardiac troponin I. A marker with high specificity for cardiac injury.Circulation, 1993
- Cardiac fatigue after prolonged exercise.Circulation, 1987
- Comparison of serum cardiac specific troponin‐I with creatine kinase, creatine kinase‐MB isoenzyme, tropomyosin, myoglobin and C‐reactive protein release in marathon runners: cardiac or skeletal muscle trauma?European Journal of Clinical Investigation, 1987
- Impaired Left Ventricular Diastolic Function in Athletes After Utterly Strenuous Prolonged ExerciseInternational Journal of Sports Medicine, 1987
- Wall stress and patterns of hypertrophy in the human left ventricle.JCI Insight, 1975