Flarer1(1938) stated that solution of quinacrine hydrochloride injected into the skin around oriental sore rapidly destroyed the parasites and cured the disease. He recommended one to four injections of 0.05 to 0.1 Gm. of quinacrine hydrochloride dissolved in 1 or 2 cc. of distilled water to be given at the first treatment and the quantity to be increased at subsequent treatments to 0.3 Gm. He also stated that with this treatment in some cases a single injection was sufficient to bring about a cure. He reported on the use of the treatment in 14 cases. The same method of treatment was used in a few cases by Cupi and Cattapan2(1942) in Eritrea, with satisfactory results. Dobrotvorskaya3(1941) elaborated the treatment originally introduced by Flarer and varied it according to the type and age of lesions. He claimed that the early dry type