TIMOLOL VERSUS PILOCARPINE SEPARATELY OR COMBINED WITH ACETAZOLAMIDE‐EFFECTS ON INTRAOCULAR PRESSURE

Abstract

Patients (58) with intraocular hypertension or primary open angle glaucoma participated in a double masked randomized study. Timolol in concentrations 0.25% and 0.5% was compared with 1, 2 or 4% pilocarpine. Acetazolamide (250 mg .times. 3) was added if intraocular pressure (IOP) was uncontrolled with the highest concentrations tested. No statistical difference was found in hypotensive effect between pilocarpine and timolol on ocular hypertensions or glaucomas. The additive hypotensive effect of acetazolamide was the same for both substances. Once a day administration of timolol was sufficient in 17 of 20 cases controlled merely by topical administration.