Gut adaptation and the glucagon-like peptides
Open Access
- 1 March 2002
- Vol. 50 (3), 428-435
- https://doi.org/10.1136/gut.50.3.428
Abstract
The glucagon-like peptides GLP-1 and GLP-2 are synthesised and then released from enteroendocrine cells in the small and large intestine. GLP-1 promotes efficient nutrient assimilation while GLP-2 regulates energy absorption via effects on nutrient intake, gastric acid secretion and gastric emptying, nutrient absorption, and mucosal permeability. Preliminary human studies indicate that GLP-2 may enhance energy absorption and reduce fluid loss in subjects with short bowel syndrome suggesting that GLP-2 functions as a key regulator of mucosal integrity, permeability, and nutrient absorption. Hence GLP-2 may be therapeutically useful in diseases characterised by injury or dysfunction of the gastrointestinal epithelium.Keywords
This publication has 101 references indexed in Scilit:
- In Vivo and in Vitro Degradation of Glucagon-Like Peptide-2 in HumansJournal of Clinical Endocrinology & Metabolism, 2000
- Circulating and Tissue Forms of the Intestinal Growth Factor, Glucagon-Like Peptide-2Endocrinology, 1997
- ENTEROGLUCAGONAnnual Review of Physiology, 1997
- Comparison of the Effects of Transforming Growth Factor α and Epidermal Growth Factor on Gastrointestinal Proliferation and Hormone ReleaseDigestion, 1996
- Trophic effect of glucagon-(1-21)-peptide on the isolated rat ileal mucosal cellsBiochemical and Biophysical Research Communications, 1988
- Influence of somatostatin and bombesin on plasma enteroglucagon and cell proliferation after intestinal resection in the rat.Gut, 1985
- Plasma enteroglucagon and CCK levels and cell proliferation in defunctioned small bowel in the ratDigestive Diseases and Sciences, 1984
- Glucagonoma syndrome demonstrating giant duodenal villi.Gut, 1984
- Gut Hormones in Inflammatory Bowel DiseaseScandinavian Journal of Gastroenterology, 1983
- Plasma Enteroglucagon after Jejunoileal Bypass with 3:1 or 1:3 Jejunoileal RatioScandinavian Journal of Gastroenterology, 1979