Gamma-lactams—A novel scaffold for highly potent and selective α7 nicotinic acetylcholine receptor agonists
- 1 March 2009
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 19 (5), 1287-1291
- https://doi.org/10.1016/j.bmcl.2009.01.073
Abstract
No abstract availableKeywords
This publication has 14 references indexed in Scilit:
- The selective nicotinic acetylcholine receptor α7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and painNeuropharmacology, 2009
- Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: In vitro and in vivo activityBioorganic & Medicinal Chemistry Letters, 2008
- Nicotinic Receptors and the Treatment of Attentional and Cognitive Deficits in Neuropsychiatric Disorders: Focus on the α7 Nicotinic Acetylcholine Receptor as a Promising Drug Target for SchizophreniaCentral Nervous System Agents in Medicinal Chemistry, 2007
- JN403, in vitro characterization of a novel nicotinic acetylcholine receptor α7 selective agonistNeuroscience Letters, 2007
- Effect of ispronicline, a neuronal nicotinic acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI)Journal of Psychopharmacology, 2007
- Neuronal Nicotinic Acetylcholine Receptors: Structural Revelations, Target Identifications, and Therapeutic InspirationsJournal of Medicinal Chemistry, 2005
- Coupling of human nicotinic acetylcholine receptors α7 to calcium channels in GH3 cellsNeuropharmacology, 2005
- Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsisNature Medicine, 2004
- Study of the calcium dynamics of the human α4β2, α3β4 and α1β1γδ nicotinic acetylcholine receptorsNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 2002
- The ensemble approach to distance geometry: application to the nicotinic pharmacophoreJournal of Medicinal Chemistry, 1986