Nucleotide sequences at host–proviral junctions for mouse mammary tumour virus
- 31 December 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 289 (5795), 253-258
- https://doi.org/10.1038/289253a0
Abstract
Proviruses cloned from rat cells infected with mouse mammary tumour virus, a B-type retrovirus regulated by glucocorticoid hormones, show the structural features of transposable elements: short inverted repeats conclude long direct repeats at the ends of viral DNA, and short sequences of cellular DNA are duplicated during integration and flank each provirus. The integrative mechanism joins a precise site in viral DNA to non-homologous sites in host DNA.Keywords
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